Abstract
Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Antioxidants / metabolism*
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / prevention & control*
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Drugs, Chinese Herbal / therapeutic use
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Exercise / physiology*
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Humans
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NF-E2-Related Factor 2 / metabolism*
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Oxidative Stress
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Phytochemicals / therapeutic use
Substances
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Antioxidants
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Drugs, Chinese Herbal
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NF-E2-Related Factor 2
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NFE2L2 protein, human
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Phytochemicals
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Protandim