The role of Nrf2 in the attenuation of cardiovascular disease

Exerc Sport Sci Rev. 2013 Jul;41(3):162-8. doi: 10.1097/JES.0b013e3182948a1e.

Abstract

Oxidative stress is a component of many human diseases, including cardiovascular diseases (CVD). Exercise and various phytochemicals activate nuclear factor (erythroid-derived 2)-like 2 (Nrf2), the master regulator of antioxidant defenses, and attenuate CVD. This review highlights Nrf2 regulation by exercise and phytochemicals and the role of Nrf2 as a therapeutic target in CVD.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Antioxidants / metabolism*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / prevention & control*
  • Drugs, Chinese Herbal / therapeutic use
  • Exercise / physiology*
  • Humans
  • NF-E2-Related Factor 2 / metabolism*
  • Oxidative Stress
  • Phytochemicals / therapeutic use

Substances

  • Antioxidants
  • Drugs, Chinese Herbal
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • Phytochemicals
  • Protandim