QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications

Chem Commun (Camb). 2013 May 11;49(38):3985-7. doi: 10.1039/c3cc39104c. Epub 2013 Apr 4.

Abstract

The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Cisplatin / administration & dosage*
  • Cisplatin / chemistry
  • Cisplatin / pharmacology
  • Drug Delivery Systems
  • Humans
  • Light
  • Luminescence
  • Male
  • Micelles*
  • Optical Imaging / methods*
  • Prodrugs / administration & dosage*
  • Prodrugs / chemistry
  • Prodrugs / pharmacology
  • Prostate / drug effects
  • Prostatic Neoplasms / drug therapy
  • Quantum Dots*
  • Tomography, Emission-Computed, Single-Photon / methods*

Substances

  • Antineoplastic Agents
  • Micelles
  • Prodrugs
  • Cisplatin