Abstract
The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / administration & dosage*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Cell Line, Tumor
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Cisplatin / administration & dosage*
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Cisplatin / chemistry
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Cisplatin / pharmacology
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Drug Delivery Systems
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Humans
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Light
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Luminescence
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Male
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Micelles*
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Optical Imaging / methods*
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Prodrugs / administration & dosage*
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Prodrugs / chemistry
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Prodrugs / pharmacology
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Prostate / drug effects
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Prostatic Neoplasms / drug therapy
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Quantum Dots*
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Tomography, Emission-Computed, Single-Photon / methods*
Substances
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Antineoplastic Agents
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Micelles
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Prodrugs
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Cisplatin