Inducible graphene oxide probe for high-specific tumor diagnosis

Chem Commun (Camb). 2013 May 10;49(37):3902-4. doi: 10.1039/c3cc40499d.

Abstract

A revolutionary probe was constructed by conjugating Cy5 on a graphene oxide sheet. The fluorescence was quenched owing to its proximity to graphene oxide in normal circumstances, but lit on arriving at the tumor site. Both in vitro and in vivo studies demonstrated that the probe exhibits great potential for tumor diagnosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbocyanines
  • Carcinoma, Lewis Lung / diagnosis*
  • Carcinoma, Lewis Lung / pathology
  • Cell Line, Tumor
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Fluorescent Dyes
  • Graphite / chemistry*
  • Humans
  • Injections, Intralesional
  • Maleimides / chemistry
  • Metalloproteases / analysis*
  • Metalloproteases / antagonists & inhibitors
  • Mice
  • Molecular Imaging
  • Molecular Probes / chemical synthesis*
  • Nanoparticles / chemistry
  • Neoplasm Proteins / analysis*
  • Neoplasm Proteins / antagonists & inhibitors
  • Oligopeptides / chemical synthesis
  • Oxides
  • Protein Interaction Domains and Motifs
  • Spectrometry, Fluorescence

Substances

  • Carbocyanines
  • Enzyme Inhibitors
  • Fluorescent Dyes
  • Maleimides
  • Molecular Probes
  • Neoplasm Proteins
  • Oligopeptides
  • Oxides
  • cyanine dye 5
  • Graphite
  • Metalloproteases