To assess the treatment of hyperpigmentation, a series of 5 case studies were conducted to evaluate the efficacy and tolerability of a novel hydroquinone-free treatment regimen combining a multimodal skin brightener with a cleanser, high strength retinol product and sunscreen SPF 30+. Patients presented with moderate to severe facial hyperpigmentation as determined by a score of 4 to 8 on the Overall Hyperpigmentation scale. Physician-graded Overall Hyperpigmentation, Global Improvement in Hyperpigmentation, and standardized photography were conducted at weeks 3, 6, and 12. At week 12, the majority of patients demonstrated Global Improvements in Hyperpigmentation of at least 50%, with at least a 2-grade reduction in Overall Hyperpigmentation scores, as assessed by the physician. Standardized photographs also support the physician and patient findings. Results from these case studies demonstrate that this unique 12-week treatment regimen can provide an effective and simple option for patients with facial hyperpigmentation.