Transcranial Doppler is a non-invasive, non-ionizing ultrasound-based imaging modality that is inexpensive with a short learning curve. It can be performed and interpreted at the bedside. This review explores the value of the transcranial Doppler technique as a confirmatory tool for brain death. The early confirmation of brain death enables the treating physicians in early decision-making and family counseling toward better care approaches, including the option of organ donation for transplantation at the appropriate time. We recommend this modality be incorporated as part of the brain death criteria in the Saudi Arabian health care system guidelines and utilized in different tiers of our hospital system.