Abstract
Atypical femoral fractures have attracted a great deal of attention and controversy in the osteoporosis community because of their association with prolonged bisphosphonate therapy. The purpose of this article is to review the epidemiologic evidence linking bisphosphonates to atypical fractures and to highlight the potential pathologic mechanisms involved in such fractures. A management plan is provided based on the available evidence.
Copyright © 2013. Published by Elsevier Inc.
MeSH terms
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Aged
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Biomechanical Phenomena
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Bone Density / drug effects
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Bone Density / physiology
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Bone Density Conservation Agents / therapeutic use
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Bone Remodeling / drug effects
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Diphosphonates / administration & dosage*
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Diphosphonates / adverse effects*
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Femoral Fractures / chemically induced*
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Femoral Fractures / physiopathology
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Hip Fractures / chemically induced*
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Hip Joint / diagnostic imaging
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Humans
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Osteoporosis / drug therapy*
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Radiography
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Teriparatide / therapeutic use
Substances
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Bone Density Conservation Agents
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Diphosphonates
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Teriparatide