Longitudinal MRI study of the midline brain regions in first-episode schizophrenia

Tsutomu Takahashi; Kazue Nakamura; Eiji Ikeda; Atsushi Furuichi; Mikio Kido; Yumiko Nakamura; Yasuhiro Kawasaki; Kyo Noguchi; Hikaru Seto; Michio Suzuki

doi:10.1016/j.pscychresns.2012.12.001

Longitudinal MRI study of the midline brain regions in first-episode schizophrenia

Psychiatry Res. 2013 May 30;212(2):150-3. doi: 10.1016/j.pscychresns.2012.12.001. Epub 2013 Mar 28.

Authors

Tsutomu Takahashi¹, Kazue Nakamura, Eiji Ikeda, Atsushi Furuichi, Mikio Kido, Yumiko Nakamura, Yasuhiro Kawasaki, Kyo Noguchi, Hikaru Seto, Michio Suzuki

Affiliation

¹ Department of Neuropsychiatry, University of Toyama, Toyama, Japan; Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan. tsutomu@med.u-toyama.ac.jp

PMID: 23541397
DOI: 10.1016/j.pscychresns.2012.12.001

Abstract

This magnetic resonance imaging (MRI) study investigated the prevalence and size of the adhesio interthalamica (AI) and cavum septi pellucidi (CSP) in 64 first-episode schizophrenia patients and 64 controls, of whom longitudinal data were available for 20 patients and 21 controls. The AI was shorter in the patients and showed longitudinal decline in both groups; there was also a trend for AI atrophy to correlate with negative symptoms. The CSP showed no group difference. These results suggest a role for the AI as a possible neurodevelopmental marker of schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Analysis of Variance
Brain / pathology*
Female
Humans
Image Processing, Computer-Assisted
Longitudinal Studies
Magnetic Resonance Imaging
Male
Schizophrenia / pathology*
Young Adult