Reprogramming by cell fusion: boosted by Tets

Gabriella Ficz; Wolf Reik

doi:10.1016/j.molcel.2013.03.014

Reprogramming by cell fusion: boosted by Tets

Mol Cell. 2013 Mar 28;49(6):1017-8. doi: 10.1016/j.molcel.2013.03.014.

Authors

Gabriella Ficz¹, Wolf Reik

Affiliation

¹ Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK.

PMID: 23541036
DOI: 10.1016/j.molcel.2013.03.014

Abstract

Pluripotent cells, when fused with somatic cells, have the dominant ability to reprogram the somatic genome. Work by Piccolo et al. (2013) shows that the Tet1 and Tet2 hydroxylases are important for DNA methylation reprogramming of pluripotency genes and parental imprints.

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