The purpose of this study was to evaluate the design of resin-bonded fixed partial dentures (RBFPDs) with zirconia frameworks. The abutment teeth were the upper central incisor and the canine. Three types of frameworks were fabricated as follows: 0.5-mm- and 0.8-mm-thick zirconia frameworks with grooves and holes (0.5ZrG, 0.8ZrG) and 0.5-mm-thick zirconia frameworks without grooves and holes (0.5Zr). The control group was designed as a 0.8-mm-thick metal framework with grooves and holes (0.8MG). Static loading was applied and the surface strain of the retainers was measured with strain gages. The magnitude of the principal strain of the 0.5ZrG framework was significantly lower than that of the 0.8MG and the 0.5Zr frameworks. This result suggests that the zirconia and retention form had a significant effect on decreasing the framework deformation, indicating that the RBFPDs that use a 0.5-mm thick zirconia framework are effective for replacing a single anterior missing tooth.