Folate, vitamin B₁₂, and S-adenosylmethionine

Teodoro Bottiglieri

doi:10.1016/j.psc.2012.12.001

Folate, vitamin B₁₂, and S-adenosylmethionine

Psychiatr Clin North Am. 2013 Mar;36(1):1-13. doi: 10.1016/j.psc.2012.12.001.

Author

Teodoro Bottiglieri¹

Affiliation

¹ Institute of Metabolic Disease, Baylor Research Institute, Baylor University, 3812 Elm Street, Dallas, TX 75226, USA. teodorob@baylorhealth.edu

PMID: 23538072
DOI: 10.1016/j.psc.2012.12.001

Abstract

Folate (vitamin B9) and cobalamin (vitamin B12) are essential for the normal development and function of the central nervous system. The metabolism of these vitamins is intimately linked and supports the synthesis of S-adenosylmethionine (SAMe), the major methyl group donor in methylation reactions. This article reviews the metabolic and clinical importance of folate, vitamin B12, and SAMe, as well as clinical trials in relation to depression and dementia.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Dementia / drug therapy*
Depression / drug therapy*
Folic Acid / therapeutic use*
Humans
S-Adenosylmethionine / therapeutic use*
Vitamin B 12 / therapeutic use*

Substances

S-Adenosylmethionine
Folic Acid
Vitamin B 12