Abstract
A variety of transcription factors has been shown to regulate lineage commitment in the mammary gland and to be associated with different molecular subtypes of breast cancer. E74-like factor 5 (Elf5) has now been identified as a marker of oestrogen receptor status, and high expression correlates with more aggressive basal cancers and resistance to anti-oestrogens. Manipulation of Elf5 transcript levels perturbs the molecular profiles of luminal and basal subtypes, highlighting the possibility that targeting Elf5 could provide a new approach for the treatment of basal cancers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / therapeutic use*
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Breast Neoplasms / classification
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism
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DNA-Binding Proteins / antagonists & inhibitors*
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DNA-Binding Proteins / metabolism
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Drug Resistance, Neoplasm / drug effects*
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Female
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Humans
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Proto-Oncogene Proteins c-ets / antagonists & inhibitors*
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Proto-Oncogene Proteins c-ets / metabolism
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Transcription Factors / antagonists & inhibitors*
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Transcription Factors / metabolism
Substances
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Antineoplastic Agents
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DNA-Binding Proteins
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ELF5 protein, human
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Elf5 protein, mouse
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Proto-Oncogene Proteins c-ets
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Transcription Factors