Normal dendritic cell mobilization to lymph nodes under conditions of severe lymphatic hypoplasia

J Immunol. 2013 May 1;190(9):4608-20. doi: 10.4049/jimmunol.1202600. Epub 2013 Mar 25.

Abstract

To address the requirement for lymphatic capillaries in dendritic cell (DC) mobilization from skin to lymph nodes (LNs), we used mice bearing one inactivated allele of vascular endothelial growth factor receptor 3 (VEGFR3) where skin lymphatic capillaries are reported absent. Unexpectedly, DC mobilization from the back skin to draining LNs was similar in magnitude, and kinetics to control mice and humoral immunity appeared intact. By contrast, DC migration from body extremities, including ear and forepaws, was ablated. An evaluation in different regions of skin revealed rare patches of lymphatic capillaries only in body trunk areas where migration was intact. That is, whereas the ear skin was totally devoid of lymphatic capillaries, residual capillaries in the back skin were present though retained only at ∼10% normal density. This reduction in density markedly reduced the clearance of soluble tracers, indicating that normal cell migration was spared under conditions when lymphatic transport function was poor. Residual lymphatic capillaries expressed slightly higher levels of CCL21 and migration of skin DCs to LNs remained dependent on CCR7 in Chy mice. DC migration from the ear could be rescued by the introduction of a limited number of lymphatic capillaries through skin transplantation. Thus, the development of lymphatic capillaries in the skin of body extremities was more severely impacted by a mutant copy of VEGFR3 than trunk skin, but lymphatic transport function was markedly reduced throughout the skin, demonstrating that even under conditions when a marked loss in lymphatic capillary density reduces lymph transport, DC migration from skin to LNs remains normal.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Movement / immunology*
  • Chemokine CCL21 / immunology
  • Chemokine CCL21 / metabolism
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Dendritic Cells / pathology
  • Dermis / immunology*
  • Dermis / metabolism
  • Dermis / transplantation
  • Inflammation / immunology
  • Inflammation / metabolism
  • Inflammation / pathology
  • Lymph / immunology
  • Lymph / metabolism
  • Lymph Nodes / immunology*
  • Lymph Nodes / metabolism
  • Lymph Nodes / pathology
  • Lymphangiogenesis / immunology
  • Lymphatic Vessels / immunology
  • Lymphatic Vessels / metabolism
  • Male
  • Mice
  • Mice, Inbred C3H
  • Mice, Inbred C57BL
  • Skin Transplantation / immunology
  • Vascular Endothelial Growth Factor Receptor-3 / immunology
  • Vascular Endothelial Growth Factor Receptor-3 / metabolism

Substances

  • Chemokine CCL21
  • Vascular Endothelial Growth Factor Receptor-3