Abstract
Because of their suitable bio-mechanical properties, polymeric materials, such as Poly(L-lactic acid) (PLLA), and poly (lactic-co-glycolic acid) (PLGA), are often used in the biomedical field, in particular for cardiovascular applications. Implanted materials induce several events related to the inflammatory reaction, such as macrophage adhesion and activation with following cytokine release. This work considered the effect of macrophage adhesion and related cytokine release on endothelial cells (PAOEC) proliferation and migration. Slight differences have been shown by the macrophages reaction when in contact with PLLA, PLGA, or PLLA/PLGA blend. However, these differences showed to differently enhance endothelial cells behavior in terms of wound healing. These data suggest the inflammatory reaction as a useful way to consider concerning materials biocompatibility, in order to optimize the endothelial regeneration following vascular prosthetic implants.
Keywords:
PLGA; PLLA; cytokines; endothelial regeneration; wound healing.
Copyright © 2013 Wiley Periodicals, Inc.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biocompatible Materials / pharmacology*
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Cardiovascular System / drug effects
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Cardiovascular System / pathology*
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Culture Media, Conditioned / pharmacology
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Cytokines / biosynthesis
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Endothelial Cells / drug effects
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Endothelial Cells / enzymology
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Endothelial Cells / pathology
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Endothelium, Vascular / drug effects
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Endothelium, Vascular / pathology*
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Endothelium, Vascular / physiopathology
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Enzyme Activation / drug effects
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Extracellular Signal-Regulated MAP Kinases / metabolism
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Humans
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Inflammation / pathology*
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Lactic Acid / pharmacology
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Monocytes / drug effects
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Monocytes / metabolism
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Monocytes / ultrastructure
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Polyglycolic Acid / pharmacology
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Polylactic Acid-Polyglycolic Acid Copolymer
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Regeneration
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Signal Transduction / drug effects
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Sus scrofa
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Wound Healing / drug effects
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rac1 GTP-Binding Protein / metabolism
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rho GTP-Binding Proteins / metabolism
Substances
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Biocompatible Materials
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Culture Media, Conditioned
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Cytokines
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Polylactic Acid-Polyglycolic Acid Copolymer
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Polyglycolic Acid
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Lactic Acid
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Extracellular Signal-Regulated MAP Kinases
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rac1 GTP-Binding Protein
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rho GTP-Binding Proteins