Molecular insights into the reversible formation of tau protein fibrils

Chem Commun (Camb). 2013 May 4;49(34):3582-4. doi: 10.1039/c3cc00241a.

Abstract

We computationally and experimentally showed that tau protein fibrils can be formed at high temperature. When cooled, the fibrils dissociate back to monomers. Heparin promotes tau fibril formation and prevents its reversion. Our results revealed the physicochemical mechanism of reversible formation of tau fibrils.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amyloid / chemistry*
  • Heparin / chemistry
  • Hot Temperature
  • tau Proteins / chemistry*

Substances

  • Amyloid
  • tau Proteins
  • Heparin