Abstract
Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.
Keywords:
CpG ODN; antigens; co-delivery; dual-mode imaging; immune.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies / analysis
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Antibodies / immunology
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Antigens / chemistry*
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Antigens / immunology
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Cell Line, Tumor
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Coordination Complexes / chemistry
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CpG Islands
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Cytokines / metabolism
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Enzyme-Linked Immunosorbent Assay
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Gadolinium / chemistry
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Lanthanoid Series Elements / chemistry*
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Magnetic Resonance Imaging
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Metal Nanoparticles / chemistry*
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Mice
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Mice, Inbred C57BL
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Neoplasms / diagnostic imaging
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Oligodeoxyribonucleotides / chemistry*
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Ovalbumin / chemistry
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Ovalbumin / immunology
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Radiography
Substances
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Antibodies
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Antigens
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Coordination Complexes
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Cytokines
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Lanthanoid Series Elements
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Oligodeoxyribonucleotides
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Ovalbumin
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Gadolinium