Combination delivery of antigens and CpG by lanthanides-based core-shell nanoparticles for enhanced immune response and dual-mode imaging

Adv Healthc Mater. 2013 Oct;2(10):1309-13. doi: 10.1002/adhm.201200364. Epub 2013 Mar 25.

Abstract

Europium-doped GdPO4 hollow spheres/polymer core-shell nanoparticles are functionalized with ovalbumin (OVA) as a model antigen and an oligonucleotide (CpG) that stimulates the immune response. These functionalized core-shell nanoparticles are used as vaccines, where they enable efficient delivery of an antigen to target sites, tracking of the vaccines using non-invasive clinical imaging technology.

Keywords: CpG ODN; antigens; co-delivery; dual-mode imaging; immune.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies / analysis
  • Antibodies / immunology
  • Antigens / chemistry*
  • Antigens / immunology
  • Cell Line, Tumor
  • Coordination Complexes / chemistry
  • CpG Islands
  • Cytokines / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • Gadolinium / chemistry
  • Lanthanoid Series Elements / chemistry*
  • Magnetic Resonance Imaging
  • Metal Nanoparticles / chemistry*
  • Mice
  • Mice, Inbred C57BL
  • Neoplasms / diagnostic imaging
  • Oligodeoxyribonucleotides / chemistry*
  • Ovalbumin / chemistry
  • Ovalbumin / immunology
  • Radiography

Substances

  • Antibodies
  • Antigens
  • Coordination Complexes
  • Cytokines
  • Lanthanoid Series Elements
  • Oligodeoxyribonucleotides
  • Ovalbumin
  • Gadolinium