We present a case of a 40-year-old female with severe keratouveitis secondary to Euphorbia trigona plant sap. The patient dropped sap into both eyes to relieve itching and developed Euphorbia keratouveitis. Visual acuity was finger counting at 1 m in both eyes on presentation. On examination, eyelid edema, ciliary injection, corneal edema with Descemet membrane folds and exudate in the anterior chamber were seen bilaterally. With supportive treatment all signs and symptoms were relieved. Exposure to Euphorbia sap should be treated immediately to prevent sequelae like corneal scarring.