Structural and biological implications of the binding of Leu-enkephalin and its metal derivatives to opioid receptors

Dalton Trans. 2013 Jul 21;42(27):9799-802. doi: 10.1039/c3dt50635e. Epub 2013 Mar 22.

Abstract

Binding of Leu-enkephalin and [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin to the recently published crystal structures of the μ- and δ-opioid receptor is studied. Docking of free Leu-enkephalin reveals two preferred conformations, one of which suggests an alternative binding site for the tyrosine residue. Furthermore, the three-dimensional solution structure of [Rh(III)(η(5)-Cp*)(η(6)-Tyr(1))]Leu-enkephalin was solved by using 2D NMR spectroscopic techniques.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Crystallography, X-Ray
  • Enkephalin, Leucine / chemistry*
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Receptors, Opioid / chemistry*
  • Rhodium / chemistry*

Substances

  • Organometallic Compounds
  • Receptors, Opioid
  • Enkephalin, Leucine
  • Rhodium