Abstract
A series of novel N-linked diglycose derivatives 9 and 10 were conveniently and directly synthesized based on the key step of one-pot tandem Staudinger/aza-Wittig/reduction reaction from the azido sugar and sugar-derived aldehyde followed by deprotection. The biological activities against glycosidases (α-amylase, α-glucosidase, and β-glucosidase) and HIV-RT and antitumor activity of these compounds were preliminarily evaluated.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry
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Amines / chemistry
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Carbohydrate Conformation
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Chemistry Techniques, Synthetic
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Disaccharidases / chemical synthesis*
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Disaccharidases / pharmacology*
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Drug Evaluation, Preclinical / methods
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Glycoside Hydrolase Inhibitors
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HIV Reverse Transcriptase / antagonists & inhibitors
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HeLa Cells / drug effects
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Humans
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alpha-Amylases / antagonists & inhibitors
Substances
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Aldehydes
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Amines
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Anti-HIV Agents
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Antineoplastic Agents
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Enzyme Inhibitors
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Glycoside Hydrolase Inhibitors
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HIV Reverse Transcriptase
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Disaccharidases
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alpha-Amylases