Analysis of factors influencing the development of xerostomia during intensity-modulated radiotherapy

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jun;115(6):772-9. doi: 10.1016/j.oooo.2013.01.006. Epub 2013 Mar 22.

Abstract

Objectives: Factors influencing xerostomia during intensity-modulated radiation therapy (IMRT) were assessed.

Methods: A 6-week study of 32 head and neck cancer (HNC) patients was performed. Subjects completed the Xerostomia Inventory (XI) and provided stimulated saliva (SS) at baseline, week 2 and at end of IMRT. Influence of SS flow rate (SSFR), calcium and mucin 5b (MUC5b) concentrations and radiation dose on xerostomia was determined.

Results: HNC subjects experienced mean SSFR decline of 36% by visit 2 (N = 27; P = .012) and 57% by visit 3 (N = 20; P = .0004). Concentrations of calcium and MUC5b increased, but not significantly during IMRT (P > .05). Xerostomia correlated most with decreasing salivary flow rate as determined by Spearman correlations (P < .04) and linear mixed models (P < .0001).

Conclusions: Although IMRT is sparing to the parotid glands, it has an early effect on SSFR and the constituents in saliva in a manner that is associated with the perception of xerostomia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Calcium / analysis*
  • Enzyme-Linked Immunosorbent Assay
  • Head and Neck Neoplasms / radiotherapy*
  • Humans
  • Linear Models
  • Middle Aged
  • Mucin-5B / analysis*
  • Radiotherapy / adverse effects
  • Radiotherapy / methods
  • Saliva / chemistry*
  • Surveys and Questionnaires
  • Xerostomia / diagnosis
  • Xerostomia / etiology*

Substances

  • Mucin-5B
  • Calcium