Association of PvuII polymorphism in ESR1 gene with impaired ovarian reserve in patients from Ukraine

Ganna Livshyts; Svetlana Podlesnaja; Sergey Kravchenko; Ludmila Livshits

doi:10.1016/j.repbio.2013.01.178

Association of PvuII polymorphism in ESR1 gene with impaired ovarian reserve in patients from Ukraine

Reprod Biol. 2013 Mar;13(1):96-9. doi: 10.1016/j.repbio.2013.01.178. Epub 2013 Jan 31.

Authors

Ganna Livshyts¹, Svetlana Podlesnaja, Sergey Kravchenko, Ludmila Livshits

Affiliation

¹ Department of Human Genomics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, Kiev, Ukraine.

PMID: 23522078
DOI: 10.1016/j.repbio.2013.01.178

Abstract

The association of ESR1 PvuII polymorphism (rs2334693) with impaired ovarian reserve was studied by genotyping this polymorphism using PCR-RFLP in patients and two control groups from Ukraine. Statistically significant differences in the prevalence of p-allele frequency (-397T) was seen in the group of patients with impaired ovarian reserve (0.597) compared to control groups I under 35years (0.480) and II over 35years (0.453), both p<0.05. The data suggest that PvuII polymorphism of ESR1 is associated with diminished ovarian reserve.

MeSH terms

Adult
Case-Control Studies
Estrogen Receptor alpha / genetics*
Female
Humans
Oogenesis
Polymorphism, Genetic
Primary Ovarian Insufficiency / genetics*
Ukraine

Substances

ESR1 protein, human
Estrogen Receptor alpha