Palladium-catalyzed direct α-arylation of methyl sulfones with aryl bromides

Bing Zheng; Tiezheng Jia; Patrick J Walsh

doi:10.1021/ol400472v

Palladium-catalyzed direct α-arylation of methyl sulfones with aryl bromides

Org Lett. 2013 Apr 5;15(7):1690-3. doi: 10.1021/ol400472v. Epub 2013 Mar 21.

Authors

Bing Zheng¹, Tiezheng Jia, Patrick J Walsh

Affiliation

¹ Department of Applied Chemistry, China Agricultural University, Beijing 100193, PR China.

PMID: 23517309
DOI: 10.1021/ol400472v

Abstract

A direct and efficient approach for palladium-catalyzed arylation of aryl and alkyl methyl sulfones with aryl bromides has been developed. The catalytic system affords arylated sulfones in good to excellent yields (73-90%).

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis
Dimethyl Sulfoxide
Hydrocarbons, Brominated / chemistry*
Palladium / chemistry*
Sulfones / chemical synthesis*
Sulfones / chemistry*

Substances

Hydrocarbons, Brominated
Sulfones
Palladium
dimethyl sulfone
Dimethyl Sulfoxide