The role of religious leaders in improving vaccination coverage has not been well researched. This intervention study investigated the role of a health education campaign and peer spiritual leaders in improving vaccination coverage rates in Akre district in Kurdistan region, Iraq. An information campaign was conducted in 30 villages with low vaccination coverage. The participation of peer spiritual leaders was sought in 15 villages of the Sorchi tribe known to have persistent low coverage rates. The vaccination coverage rates of DPT1, DPT2, DPT3 and measles vaccines during the post-intervention period (January to June 2007) were significantly improved (95.5%, 90.0%, 84.4% and 80.3% respectively) compared with the pre-intervention period (January to June 2006) (55.9%, 42.7%, 21.5% and 27.6% respectively). The dropout rates of those vaccines were also significantly decreased. Vaccination in villages where spiritual leaders were involved improved significantly more than other villages.