The standard Caldwell-Luc procedure includes the removal of most of the maxillary sinus mucosa and the introduction of an inferior meatal antrostomy to promote sinus drainage. Pain, chronic relapsing inflammation and loss of volume are typical sequels of this procedure. Partial maxillary resection and iliac crest bone graft harvesting is a new concept and treatment option in such cases. The case of a 64-year-old woman who had previously undergone several unilateral sinus operations is presented. Fluorescein imaging was used to detect bone areas of low blood perfusion in the sinus walls. All affected bone and granulation tissue were removed. After resection, an iliac crest bone graft with vascular pedicle was performed to reconstruct the maxillary defect. Postoperative CT and scintigraphic imaging revealed a vital transplant. At the 10-month follow-up, no inflammation was observed and chronic pain was significantly reduced. The results clearly demonstrate that maxillary resection and iliac crest bone graft harvesting might be an option to treat severe cases of chronic sinusitis. Further prospective studies are necessary to confirm the advantages of this technique.