Abstract
Computational redesign of a dimorphic protein nano-cage at the C3-symmetrical interfaces forces it to assemble into the monomorphic cage. These monodisperse assemblies are at least 20 °C more stable than the parent. This approach adds to the toolkit of bottom-up molecular design with applications in protein engineering and hybrid nano-materials.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacterial Proteins / chemistry*
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Bacterial Proteins / genetics
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Cytochrome b Group / chemistry*
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Cytochrome b Group / genetics
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Ferritins / chemistry*
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Ferritins / genetics
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Mutation
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Nanostructures / chemistry*
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Protein Conformation
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Protein Engineering
Substances
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Bacterial Proteins
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Cytochrome b Group
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Ferritins
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bacterioferritin