Abstract
In this work we describe the fabrication of a biocompatible hydrophilic scaffold composed of cross-linked gelatin that mimics the porous three-dimensional structure of pulmonary tissue as well as its water content and mechanical properties. The lung replica also reproduces the characteristic sonographic signs of pulmonary interstitial syndrome, the B-lines or ultrasound lung comets.
Keywords:
B-lines; echographic signals; gelatin; hydrogels; lung replica; mechanical properties; porosity.
MeSH terms
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Acoustics
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Biocompatible Materials / chemistry*
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Collagen / chemistry
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Cross-Linking Reagents / chemistry
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Elasticity
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Gelatin / chemistry*
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Humans
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Imaging, Three-Dimensional
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Lung / diagnostic imaging*
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Lung / physiopathology*
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Lung Diseases, Interstitial / physiopathology*
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Microscopy, Electron, Scanning
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Models, Biological
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Phantoms, Imaging*
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Porosity
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Stress, Mechanical
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Time Factors
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Tissue Scaffolds
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Ultrasonography
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Water / chemistry
Substances
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Biocompatible Materials
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Cross-Linking Reagents
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Water
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Gelatin
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Collagen