Caspase-11: the noncanonical guardian of cytosolic sanctity

Sunny Shin; Igor E Brodsky

doi:10.1016/j.chom.2013.02.011

Caspase-11: the noncanonical guardian of cytosolic sanctity

Cell Host Microbe. 2013 Mar 13;13(3):243-5. doi: 10.1016/j.chom.2013.02.011.

Authors

Sunny Shin¹, Igor E Brodsky

Affiliation

¹ Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sunshin@mail.med.upenn.edu

PMID: 23498948
DOI: 10.1016/j.chom.2013.02.011

Abstract

Caspase-11 controls a noncanonical inflammasome that responds to Gram-negative bacteria and certain pore-forming toxins. Aachoui et al. (2013) and Case et al. (2013) identify a role for caspase-11 in rapid responses to bacterial pathogens that access the cytosol via vacuolar membrane disruption or the activity of specialized secretion systems.

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