Validity of a new respiratory resistance measurement device to detect glottal area change

J Voice. 2013 May;27(3):299-304. doi: 10.1016/j.jvoice.2013.01.006. Epub 2013 Mar 15.

Abstract

Objective: To determine the correlation between respiratory resistance (Rr) values measured with the Airflow Perturbation Device (APD) to laryngoscopic images of glottal area (GA) in feigned paradoxical vocal fold motion (PVFM), also known as vocal cord dysfunction.

Hypothesis: There is a strong inverse relationship between Rr and GA such that laryngeal constriction can be detected and quantified by APD-measured Rr.

Study design: Prospective, single subject study.

Methods: A healthy adult feigned breathing that was characteristic of PVFM. Rr and GA were simultaneously recorded, synchronized, and analyzed for three complete breathing cycles with significant glottal constriction occurring during inspiration.

Results: Cross-correlation analysis revealed a strong negative correlation (-0.824) between GA and Rr during feigned PVFM breathing such that Rr increased when GA decreased.

Conclusion: APD-measured Rr appears to be a viable noninvasive method for diagnostic screening and monitoring of treatment outcomes for individuals presenting with dyspnea related to PVFM.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Validation Study

MeSH terms

  • Airway Resistance*
  • Biomechanical Phenomena
  • Constriction, Pathologic
  • Dyspnea / diagnosis*
  • Dyspnea / etiology
  • Dyspnea / physiopathology
  • Equipment Design
  • Female
  • Glottis / pathology*
  • Glottis / physiopathology
  • Humans
  • Laryngoscopy
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Reproducibility of Results
  • Respiration*
  • Respiratory Function Tests / instrumentation*
  • Stroboscopy
  • Video Recording
  • Vocal Cord Dysfunction / complications
  • Vocal Cord Dysfunction / diagnosis*
  • Vocal Cord Dysfunction / physiopathology