The FAT epidemic: a gene family frequently mutated across multiple human cancer types

Cell Cycle. 2013 Apr 1;12(7):1011-2. doi: 10.4161/cc.24305. Epub 2013 Mar 14.
No abstract available

Keywords: FAT1; cancer; mutation; signaling; tumor; tumor suppressor; wnt.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Cadherins / chemistry
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Drosophila / metabolism
  • Drosophila Proteins / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mutation
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Protein Serine-Threonine Kinases / metabolism
  • Signal Transduction
  • TCF Transcription Factors / metabolism
  • beta Catenin / metabolism

Substances

  • Cadherins
  • Drosophila Proteins
  • FAT1 protein, human
  • Intracellular Signaling Peptides and Proteins
  • TCF Transcription Factors
  • beta Catenin
  • Protein Serine-Threonine Kinases
  • hpo protein, Drosophila