Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2336-9. doi: 10.1016/j.bmcl.2013.02.061. Epub 2013 Feb 24.

Abstract

Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Carcinoma, Renal Cell / drug therapy
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Haplorhini
  • Humans
  • K562 Cells
  • Kidney Neoplasms / drug therapy
  • Mass Spectrometry
  • Nuclear Magnetic Resonance, Biomolecular
  • Pancreatic Neoplasms / drug therapy
  • Porifera / chemistry*
  • Sesterterpenes / chemistry*
  • Sesterterpenes / isolation & purification
  • Sesterterpenes / pharmacology*
  • Spectrophotometry, Infrared

Substances

  • Antineoplastic Agents
  • Sesterterpenes