Neuregulin-1 (NRG-1) and its susceptibility to schizophrenia: a case-control study and meta-analysis

Han Chern Loh; Pek Yee Tang; Shiau Foon Tee; Tze Jen Chow; Chee Yen Choong; Shen Yang Lim; Hoi Sen Yong

doi:10.1016/j.psychres.2013.01.022

Neuregulin-1 (NRG-1) and its susceptibility to schizophrenia: a case-control study and meta-analysis

Psychiatry Res. 2013 Jul 30;208(2):186-8. doi: 10.1016/j.psychres.2013.01.022. Epub 2013 Mar 9.

Authors

Han Chern Loh¹, Pek Yee Tang, Shiau Foon Tee, Tze Jen Chow, Chee Yen Choong, Shen Yang Lim, Hoi Sen Yong

Affiliation

¹ Department of Chemical Engineering, Faculty of Engineering and Science (FES), Universiti Tunku Abdul Rahman (UTAR), Jalan Genting Kelang, Setapak, 53300 Kuala Lumpur, Malaysia. hcloh@utar.edu.my

PMID: 23489597
DOI: 10.1016/j.psychres.2013.01.022

Abstract

Neuregulin-1 is widely investigated due to its hypothesised association with schizophrenia. Single-nucleotide polymorphisms rs764059, rs2954041 and rs3924999 were investigated (417 patients with schizophrenia and 429 controls). We failed to demonstrate a significant association between rs2954041 and rs3924999 with schizophrenia in the three ethnic groups studied (Malay, Chinese, and Indian), while rs764059 was found to be monomorphic.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics
Case-Control Studies
Female
Genetic Predisposition to Disease / genetics*
Humans
Male
Neuregulin-1 / genetics*
Polymorphism, Single Nucleotide
Schizophrenia / genetics*
White People / genetics

Substances

Neuregulin-1