Bromotyrosine alkaloids from the Australian marine sponge Pseudoceratina verrucosa

J Nat Prod. 2013 Apr 26;76(4):516-23. doi: 10.1021/np300648d. Epub 2013 Mar 14.

Abstract

Two new bromotyrosine alkaloids, pseudoceralidinone A (1) and aplysamine 7 (2), along with three known compounds were isolated from the Australian sponge Pseudoceratina verrucosa. Their structures were characterized by NMR and MS data and the synthetic route. Their cytotoxicity was evaluated against cancer cell lines (HeLa and PC3) and a noncancer cell line (NFF).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Australia
  • Drug Screening Assays, Antitumor
  • HeLa Cells
  • Humans
  • Hydrocarbons, Brominated / chemistry
  • Hydrocarbons, Brominated / isolation & purification*
  • Hydrocarbons, Brominated / pharmacology
  • Male
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxazoles
  • Porifera / chemistry*
  • Thiazoles / chemistry
  • Thiazoles / isolation & purification*
  • Thiazoles / pharmacology
  • Tyrosine / analogs & derivatives
  • Tyrosine / chemistry

Substances

  • Alkaloids
  • Hydrocarbons, Brominated
  • Oxazoles
  • Thiazoles
  • aplysamine 7
  • bromotyrosine
  • pseudoceralidinone A
  • Tyrosine