Effects of extracts of ginkgo, onion, and celery on the contractility of isolated rat atria

Clin Exp Hypertens. 2013;35(8):595-600. doi: 10.3109/10641963.2013.776566. Epub 2013 Mar 14.

Abstract

The acute negative inotropic and chronotropic effects of the commercial extract of ginkgo leaf (Gingium(®)) and ethanolic extracts of onion bulbs and celery root on spontaneous and noradrenalin-stimulated contractions of the Wistar rat atria were investigated. All analyzed extracts exerted negative inotropic effects on the isolated rat atria. Among the tested extracts, the extract of ginkgo showed the strongest negative inotropic effects on rat atria, either in spontaneous or noradrenalin-induced contractions, being more potent than the onion and celery extracts, respectively.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apium*
  • Depression, Chemical
  • Ginkgo biloba*
  • Heart / drug effects*
  • Heart Atria / drug effects
  • Myocardial Contraction / drug effects*
  • Onions*
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Plant Roots
  • Rats
  • Rats, Wistar

Substances

  • Plant Extracts
  • gingium