GABA predicts inhibition of frequency-specific oscillations in schizophrenia

J Neuropsychiatry Clin Neurosci. 2013 Winter;25(1):83-7. doi: 10.1176/appi.neuropsych.11120368.

Abstract

This study is the first to show a relationship between in-vivo brain gamma-amino butyric acid (GABA) levels and auditory inhibitory electrophysiological measures in schizophrenia. Results revealed a strong association between GABA levels and gating of the theta-alpha and beta activities in schizophrenia.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Brain / metabolism*
  • Brain / physiopathology*
  • Brain Mapping
  • Electroencephalography
  • Female
  • Humans
  • Inhibition, Psychological
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Schizophrenia / pathology*
  • Theta Rhythm / physiology*
  • gamma-Aminobutyric Acid / metabolism*

Substances

  • gamma-Aminobutyric Acid