Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

Aiichiro Nagaki; Daisuke Ichinari; Jun-ichi Yoshida

doi:10.1039/c3cc40392k

Reactions of organolithiums with dialkyl oxalates. A flow microreactor approach to synthesis of functionalized α-keto esters

Chem Commun (Camb). 2013 Apr 21;49(31):3242-4. doi: 10.1039/c3cc40392k. Epub 2013 Mar 13.

Authors

Aiichiro Nagaki¹, Daisuke Ichinari, Jun-ichi Yoshida

Affiliation

¹ Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, 615-8510 Kyoto, Japan.

PMID: 23486774
DOI: 10.1039/c3cc40392k

Abstract

Reactions of functionalized aryllithiums with dialkyl oxalates were achieved using a flow microreactor to obtain α-keto esters with high selectivity by virtue of fast 1 : 1 micromixing.

MeSH terms

Bromobenzenes / chemistry
Esters
Lithium / chemistry*
Organometallic Compounds / chemistry*
Oxalates / chemistry*
Temperature

Substances

Bromobenzenes
Esters
Organometallic Compounds
Oxalates
Lithium
bromobenzene