Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells
Bull Exp Biol Med. 2013 Feb;154(4):562-5.
doi: 10.1007/s10517-013-2000-0.
[Article in
English,
Russian]
Affiliation
- 1 St. Petersburg Institute of Bioregulation and Gerontology, Russian Academy of Medical Sciences, St. Petersburg, Russia.
Abstract
We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cells precursor differentiation towards CD4(+)T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.
MeSH terms
-
Animals
-
CD8-Positive T-Lymphocytes / cytology
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CD8-Positive T-Lymphocytes / drug effects
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Cell Differentiation / drug effects
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Cells, Cultured
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Dipeptides / pharmacology*
-
Humans
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Immunomodulation / drug effects
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Lymphocytes / cytology
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Lymphocytes / drug effects
-
Rats
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Rats, Wistar
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T-Lymphocyte Subsets / cytology
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T-Lymphocyte Subsets / drug effects
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Thymus Gland / cytology*
Substances
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Dipeptides
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lysylglutamic acid