Effect of supernatant from fibroblasts from the progeny of female rats with chronic liver disease of different origin on the morphology and function of cultured peritoneal macrophages

G V Bryukhin; I V Zubarev

doi:10.1007/s10517-013-1990-y

Effect of supernatant from fibroblasts from the progeny of female rats with chronic liver disease of different origin on the morphology and function of cultured peritoneal macrophages

Bull Exp Biol Med. 2013 Feb;154(4):512-4. doi: 10.1007/s10517-013-1990-y.

[Article in English, Russian]

Authors

G V Bryukhin¹, I V Zubarev

Affiliation

¹ Department of Histology, Embryology, and Cytology, Chelyabinsk State Medical Academy, Russia.

PMID: 23486594
DOI: 10.1007/s10517-013-1990-y

Abstract

We studied the effects of supernatant from ovarian fibroblasts derived from the progeny of female rats with experimental chronic liver disease of different genesis on the function of cultured allogenic peritoneal macrophages. Addition of fibroblast supernatant derived from animals with liver disease to the culture medium suppressed the function of peritoneal macrophages from intact newborn rats, which manifested in reduction of the adhesion characteristics and decrease of their phagocytic parameter and phagocytic index.

MeSH terms

Animals
Animals, Newborn
Cells, Cultured
Chronic Disease
Culture Media, Conditioned / pharmacology*
Female
Fibroblasts / cytology
Fibroblasts / metabolism*
Liver Diseases / metabolism*
Macrophages, Peritoneal / cytology*
Macrophages, Peritoneal / drug effects*
Ovary / cytology
Rats

Substances

Culture Media, Conditioned