Abstract
The gold(I)-catalyzed [2 + 2] cycloaddition of large 1,n-enynes (n = 10-16) provides access to 9- to 15-membered ring macrocycles incorporating a cyclobutene moiety. The reaction requires the use of a gold(I) catalyst bearing a sterically hindered biphenylphosphine ligand.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkynes / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Cyclization
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Gold / chemistry*
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Ligands
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Macrocyclic Compounds / chemical synthesis*
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Macrocyclic Compounds / chemistry
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Molecular Structure
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Stereoisomerism
Substances
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Alkynes
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Ligands
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Macrocyclic Compounds
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Gold