Gold(I)-catalyzed macrocyclization of 1,n-enynes

Org Lett. 2013 Apr 5;15(7):1576-9. doi: 10.1021/ol400358f. Epub 2013 Mar 13.

Abstract

The gold(I)-catalyzed [2 + 2] cycloaddition of large 1,n-enynes (n = 10-16) provides access to 9- to 15-membered ring macrocycles incorporating a cyclobutene moiety. The reaction requires the use of a gold(I) catalyst bearing a sterically hindered biphenylphosphine ligand.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Cyclization
  • Gold / chemistry*
  • Ligands
  • Macrocyclic Compounds / chemical synthesis*
  • Macrocyclic Compounds / chemistry
  • Molecular Structure
  • Stereoisomerism

Substances

  • Alkynes
  • Ligands
  • Macrocyclic Compounds
  • Gold