Abstract
Microbial studies of the Mediterranean sponge Tethya aurantium led to the isolation of the fungus Bartalinia robillardoides strain LF550. The strain produced a number of secondary metabolites belonging to the chloroazaphilones. This is the first report on the isolation of chloroazaphilones of a fungal strain belonging to the genus Bartalinia. Besides some known compounds (helicusin A (1) and deacetylsclerotiorin (2)), three new chloroazaphilones (helicusin E (3); isochromophilone X (4) and isochromophilone XI (5)) and one new pentaketide (bartanolide (6)) were isolated. The structure elucidations were based on spectroscopic analyses. All isolated compounds revealed different biological activity spectra against a test panel of four bacteria: three fungi; two tumor cell lines and two enzymes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification
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Anti-Infective Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Bacteria / drug effects
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Benzopyrans / chemistry
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Benzopyrans / isolation & purification
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Benzopyrans / pharmacology
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Cell Line, Tumor
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology
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Fungi / drug effects
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Glutarates / chemistry
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Glutarates / isolation & purification
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Glutarates / pharmacology
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Humans
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Isoquinolines / chemistry
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Isoquinolines / isolation & purification
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Isoquinolines / pharmacology
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Mediterranean Region
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Neoplasms / drug therapy
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Neoplasms / pathology
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Porifera / microbiology*
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Pyridones / chemistry
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Pyridones / isolation & purification
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Pyridones / pharmacology*
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Spectrum Analysis
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Xylariales / chemistry*
Substances
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Anti-Infective Agents
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Antineoplastic Agents
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Benzopyrans
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Enzyme Inhibitors
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Glutarates
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Isoquinolines
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Pyridones
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chloroazaphilone
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isochromophilone XI