Sex and disgust seem like strange bedfellows. The premise of this review is that disgust-based mechanisms nevertheless hold great promise for improving our understanding of sexual behavior, including dysfunctions. Disgust is a defensive emotion that protects the organism from contamination. Accordingly, disgust is focused on the border of the self, with the mouth and vagina being the body parts that show strongest disgust sensitivity. Given the central role of these organs in sexual behavior, together with the fact that bodily products are among the strongest disgust elicitors, the critical question seems not whether disgust may interfere with sex but rather how people succeed in having pleasurable sex at all. We argue that sexual arousal plays a critical role in counteracting disgust-induced avoidance via lowering the threshold for engaging in "disgusting sex." Following this, all mechanisms that interfere with the generation of sexual arousal or enhance the disgusting properties of sexual stimuli may hamper the functional transition from a sex-avoidance into an approach disposition. Since prolonged contact is the most powerful means to reduce disgust, disgust-based mechanisms that counteract sexual approach may give rise to a self-perpetuating cycle in which enhanced sexual disgust becomes a chronic feature.