[Combined effects of aluminium and immobilization stress on the reproductive system of male rats]

Med Tr Prom Ekol. 2012:(11):37-42.
[Article in Russian]

Abstract

The evaluation of the isolated and combined effects of aluminum and immobilization stress on the reproductive system of male laboratory rats has been performed. We have established the influence of these factors on spermatogenesis and spermiogenesis: the development of degenerative processes in the testes, on specific hormonal status, apoptosis, increasing abnormal forms of epididymal sperms and reducing their mobility, and on the growth of early embryonic losses. Neither synergistic nor antagonistic effect in the combined aluminum and the stress action has been found.

MeSH terms

  • Aluminum Compounds* / administration & dosage
  • Aluminum Compounds* / pharmacokinetics
  • Aluminum Compounds* / toxicity
  • Animals
  • Disease Models, Animal
  • Female
  • Injections, Intraperitoneal
  • Male
  • Nitrates* / administration & dosage
  • Nitrates* / pharmacokinetics
  • Nitrates* / toxicity
  • Rats
  • Rats, Wistar
  • Reproduction / drug effects*
  • Restraint, Physical
  • Spermatogenesis / drug effects*
  • Spermatogenesis-Blocking Agents / administration & dosage
  • Spermatogenesis-Blocking Agents / pharmacokinetics
  • Spermatogenesis-Blocking Agents / toxicity
  • Spermatozoa / drug effects*
  • Stress, Physiological*
  • Teratogens / pharmacokinetics
  • Teratogens / toxicity

Substances

  • Aluminum Compounds
  • Nitrates
  • Spermatogenesis-Blocking Agents
  • Teratogens
  • aluminum nitrate