Infrared (IR) imagery sequences are commonly used for detecting moving targets in the presence of evolving cloud clutter or background noise. This research concentrates on slow-moving point targets that are less than one pixel in size, such as aircraft at long ranges from a sensor. Because transmitting IR imagery sequences to a base unit or storing them consumes considerable time and resources, a compression method that maintains the point-target detection capabilities is highly desirable. In our previous work, we introduced two temporal compression methods that preserve the temporal profile properties of the point target in the form of discrete cosine transform (DCT) quantization and parabola fit. In the present work, we extend the compression task method of DCT quantization by applying spatial compression over the temporally compressed coefficients, which is followed by bit encoding. We evaluate the proposed compression method using a signal-to-noise ratio (SNR)-based measure for point target detection and find that it yields better results than the compression standard H.264. Furthermore, we introduce an automatic detection algorithm that extracts the target location from the SNR scores image, which is acquired during the evaluation process and has a probability of detection and a probability of false alarm close to those of the original sequences. We previously determined that it is necessary to establish a minimal noise level in the SNR-based measure to compensate for smoothing that is induced by the compression. Here, the noise level calculation process is modified in order to allow detection of targets traversing all background types.