Local administration of cyclosporin allows reduction of the dose prolonging survival of heart tissue allografts

D Górecki; A Kruszewski; M Jakóbisiak; W Lasek

doi:10.1016/0165-2478(90)90067-z

Local administration of cyclosporin allows reduction of the dose prolonging survival of heart tissue allografts

Immunol Lett. 1990 Feb;23(4):247-9. doi: 10.1016/0165-2478(90)90067-z.

Authors

D Górecki¹, A Kruszewski, M Jakóbisiak, W Lasek

Affiliation

¹ Department of Histology and Embryology, Medical School, Warsaw, Poland.

PMID: 2347600
DOI: 10.1016/0165-2478(90)90067-z

Abstract

In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclosporins / administration & dosage*
Ear, External
Female
Graft Survival / drug effects*
Heart Transplantation*
Injections, Intravenous
Injections, Subcutaneous
Male
Mice
Mice, Inbred BALB C / immunology
Mice, Inbred CBA / immunology
Transplantation, Heterotopic
Transplantation, Homologous

Substances

Cyclosporins