Electric-field-induced strains of BiScO3-PbTiO3 (BS-PT) ceramics and actuation performance in multilayer configuration were investigated in the temperature range from 25°C to 250°C. Experimental results confirmed that BS-PT ceramics showed better piezoelectric temperature stability than PZT-5H ceramics, and larger strain than PZT-4 and PZT-8 ceramics at temperatures above 50°C. The strain of a BSPT multilayer actuator prepared by the silicate-cement-glue method was comparable to that of a single-layer BS-PT ceramic. Under ±7.5 kV/cm electric field, the strain of a BS-PT multilayer actuator reached 0.115% at 200°C. Our work shows that BS-PT ceramics are suitable for high-temperature actuation applications.