Abstract
Ergotamine is used to abort or prevent vascular headache. Valvular heart disease as an adverse effect of long-term ergotamine therapy has been rarely reported in the English literature, with only a few cases published. It is hypothesized that ergot-derived agents stimulate serotonergic receptors (5-HT2B), causing proliferation of myofibroblasts, with subsequent thickening of valve leaflets and chords. This case presentation aims at increasing clinicians' awareness of this potential complication.
Georg Thieme Verlag KG Stuttgart · New York.
MeSH terms
-
Aortic Valve Insufficiency / chemically induced
-
Aortic Valve Insufficiency / surgery
-
Caffeine / adverse effects*
-
Cardiac Valve Annuloplasty*
-
Cell Proliferation / drug effects
-
Drug Combinations
-
Echocardiography, Doppler, Color
-
Ergotamine / adverse effects*
-
Female
-
Heart Valve Diseases / chemically induced
-
Heart Valve Diseases / diagnosis
-
Heart Valve Diseases / surgery*
-
Heart Valve Prosthesis Implantation*
-
Heart Valves / drug effects
-
Heart Valves / pathology
-
Heart Valves / surgery*
-
Humans
-
Middle Aged
-
Mitral Valve Insufficiency / chemically induced
-
Mitral Valve Insufficiency / surgery
-
Myofibroblasts / drug effects
-
Myofibroblasts / pathology
-
Serotonin 5-HT2 Receptor Agonists / adverse effects*
-
Treatment Outcome
-
Tricuspid Valve Insufficiency / chemically induced
-
Tricuspid Valve Insufficiency / surgery
Substances
-
Drug Combinations
-
Serotonin 5-HT2 Receptor Agonists
-
caffeine, ergotamine drug combination
-
Caffeine
-
Ergotamine