Abstract
This review summarizes our research into the synthesis and structure-activity relationships of epolactaene, neoechinulin A, plakevulin A, pseudodeflectusin and ustusorane C. These natural products are attractive in view of their apoptosis-inducing activity, cytoprotective activity against peroxynitrite, inhibitory activity against DNA polymerases, and cytotoxicity in cancer cells.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biological Products / chemical synthesis
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Biological Products / chemistry*
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Biological Products / pharmacology*
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Humans
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Organic Chemicals / chemical synthesis
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Organic Chemicals / chemistry
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Organic Chemicals / pharmacology
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Structure-Activity Relationship
Substances
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Biological Products
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Organic Chemicals