[Expression of GIRK4 gene in kidney tissues of obese rat]

Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Feb;35(1):36-9. doi: 10.3881/j.issn.1000-503X.2013.01.007.
[Article in Chinese]

Abstract

Objective: To investigate the expression of GIRK4 gene in the kidney tissues of obese rats.

Methods: Obese rat models were established using diet-induced method. The GIRK4 protein expression in kidney tissues was determined in 20 obese rats and 10 normal rats using Western blot analysis.

Results: The relative expression level of GIRK4 protein in the kidney tissues of obese rat (1.75±0.42) was significantly lower than that in normal rats (3.37±0.68, P<0.05).

Conclusion: GIRK4 has a low protein expression in the kidney tissues of obese rat.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Gene Expression
  • Kidney / metabolism*
  • Male
  • Obesity / genetics
  • Obesity / metabolism*
  • Potassium Channels, Inwardly Rectifying / genetics
  • Potassium Channels, Inwardly Rectifying / metabolism*
  • Rats

Substances

  • Kcnj5 protein, rat
  • Potassium Channels, Inwardly Rectifying