Objective: To investigate the expression of GIRK4 gene in the kidney tissues of obese rats.
Methods: Obese rat models were established using diet-induced method. The GIRK4 protein expression in kidney tissues was determined in 20 obese rats and 10 normal rats using Western blot analysis.
Results: The relative expression level of GIRK4 protein in the kidney tissues of obese rat (1.75±0.42) was significantly lower than that in normal rats (3.37±0.68, P<0.05).
Conclusion: GIRK4 has a low protein expression in the kidney tissues of obese rat.