This paper is aimed to observe the difference of facial color of people with different health status by spectral photometric color measuring technique according to the theory of facial color diagnosis in Internal Classic. We gathered the facial color information about the health status of persons in healthy group (183), sub-healthy group (287) and disease group (370) respectively. The information included L, a, b, C values and reflection of different wavelengths in 400-700nm with CM-2600D spectral photometric color measuring instrument on 8 points. The results indicated that overall complexion color values of the people in the three groups were significantly different. The persons in the disease group looked deep dark in features. The people in the sub-healthy group looked pale in features. The loci L, a, b, C values were with varying degrees of significant differences (P < 0.05) at 6 points among the groups, and the central position of the face in all the groups was the position with most significant differences. Comparing the facial color information at the same point of the people in the three groups, we obtained each group's diagnostic special point. There existed diagnostic values in distinguishing disease status and various status of health in some degree by spectral photometric color measuring technique. The present method provides a prosperous quantitative basis for Chinese medical inspection of the complexion diagnosis.