Abstract
We investigated mechanisms of the false-positive test results on rapid-antigen detection test (RADT) for group A Streptococcal (GAS) pharyngitis. Most RADT false-positives (76%) were associated with polymerase chain reaction-positive GAS results, suggesting that RADT specificity could be considered close to 100%. Finding that 61% of GAS culture-negative but RADT-positive cases were positive on both GAS polymerase chain reaction and Staphylococcus aureus testing, we posit bacterial inhibition as causative.
Copyright © 2013 Mosby, Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Antigens, Bacterial / analysis*
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Antigens, Bacterial / genetics
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Case-Control Studies
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Child
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Child, Preschool
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False Positive Reactions
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Humans
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Pharyngitis / diagnosis*
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Pharyngitis / microbiology
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Pharynx / microbiology*
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Polymerase Chain Reaction / methods
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Sensitivity and Specificity
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Staphylococcus aureus / immunology
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Staphylococcus aureus / isolation & purification*
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Streptococcal Infections / diagnosis*
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Streptococcus pyogenes / immunology
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Streptococcus pyogenes / isolation & purification*