Abstract
3, 2, 1 go! An unprecedented one-pot, catalyst-free, three-component aminomethylation of α-substituted nitroacetates, formalin, and amines has been reported, thereby enabling the highly efficient synthesis of α,β-diamino acid precursors with great structural diversity.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry*
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Catalysis
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Hydrogen Bonding
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Imidazolidines / chemical synthesis*
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Imidazolidines / chemistry
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Magnetic Resonance Spectroscopy
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Methanol / chemistry*
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Methylation
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Models, Molecular
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Molecular Structure
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Solvents / chemistry
Substances
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Acetates
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Imidazolidines
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Solvents
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nitroacetic acid
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Methanol