Soluble tag-assisted peptide head-to-tail cyclization: total synthesis of mahafacyclin B

Org Lett. 2013 Mar 15;15(6):1155-7. doi: 10.1021/ol4003477. Epub 2013 Mar 5.

Abstract

A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimalarials / chemical synthesis*
  • Antimalarials / chemistry
  • Antimalarials / pharmacology
  • Cyclization
  • Molecular Structure
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / pharmacology

Substances

  • Antimalarials
  • Peptides, Cyclic
  • mahafacyclin B